. 2018 Nov 15;104(4):1005–1019. doi: 10.1210/jc.2018-01118

Table 5.

Significantly Different Metabolites Within the Xenobiotic Superpathway, Between Groups

Subpathway	Biochemical Name	Groups
Subpathway	Biochemical Name	Infertility vs Spontaneous	IVF vs Spontaneous	NIFT vs Spontaneous	IVF vs NIFT
Xanthine metabolism	Paraxanthine	0.59^a	0.53^a	0.72	0.74
Xanthine metabolism	1,3,7-Trimethylurate	0.57^a	0.55^a	0.63^b	0.86
Xanthine metabolism	1-Methylxanthine	0.59^a	0.54^a	0.70	0.77
Xanthine metabolism	5-Acetylamino-6-formylamino-3-methyluracil	0.54^a	0.48^a	0.66	0.73
Drug (analgesics, anesthetics)	Salicyluric glucuronide	1.72^c	1.96^c	1.24	1.58
Benzoate metabolism	2-Hydroxyhippurate (salicylurate)	1.71^c	1.98^c	1.16	1.72
Benzoate metabolism	3-Hydroxyhippurate	1.69^d	2.06^c	0.95	2.18^c
Benzoate metabolism	4-Hydroxyhippurate	1.34	1.53^c	0.96	1.59^c
Benzoate metabolism	3-(3-Hydroxyphenyl) propionate sulfate	1.47^c	1.66^c	1.09	1.51^d

In the metabolome cohort, fold changes of members from subpathways of xanthine metabolism and benzoate metabolism are shown between the following groups: infertility vs spontaneous, the IVF vs spontaneous, NIFT vs spontaneous, and IVF vs NIFT. Analysis of covariance was performed, using BMI as a covariate.

^{^a}

P < 0.05 for decreased levels of metabolites.

^{^b}

0.05 < P < 0.1 for decreased levels of metabolites.

^{^c}

P < 0.05 for increased levels of metabolites.

^{^d}

0.05 < P < 0.1 for increased levels of metabolites.