Table 1.
Patient factors assessed in the population pharmacodynamic analysis
| Covariate | Type | Parameters tested |
|---|---|---|
| ECOG group | Categorical | BASE_HAZ, EMAX, EC50 |
| Tumour size | Continuous | BASE_HAZ, EMAX, EC50 |
| Tumour histology | Categorical | BASE_HAZ, EMAX, EC50 |
| Age group | Categorical | BASE_HAZ, EMAX, EC50 |
| Gender | Categorical | BASE_HAZ, EMAX, EC50 |
| Race | Categorical | BASE_HAZ, EMAX, EC50 |
| Body weight | Categorical | BASE_HAZ, EMAX, EC50 |
| Prior treatment | Categorical | BASE_HAZ, EMAX, EC50 |
| Hemoglobin | Continuous | BASE_HAZ, EMAX, EC50 |
| Albumin | Continuous | BASE_HAZ, EMAX, EC50 |
ECOG Eastern Cooperative Oncology Group, BASE_HAZ baseline hazard, EMAX maximum response achievable from a dose, EC50 concentration of a drug that gives half-maximal response