Fig. 2.

Kaplan–Meier survival curves of calpastatin and calpain-1, -2 and -4 expression, and overall survival. Survival analysis shows significantly better (P = 0.010) overall survival for ovarian cancer patients whose tumours express high calpastatin compared to those with tumours expressing low calpastatin. There were no differences in overall survival between patients with tumours expressing high calpain-1 and those with tumours expressing low calpain-1 (P = 0.153). Survival analysis showed significantly better (P = 0.026) overall survival for ovarian cancer patients whose tumours expressed low calpain-2 compared to those with tumours expressing high calpain-2. Survival analysis also showed significantly better (P = 0.003) overall survival for patients with tumours expressing high calpain-4 compared to those expressing low calpain-4. Significance was determined using the log-rank test. The tables shown below the Kaplan–Meier survival curves listed the number of patients at risk at the specific months. High expression—black line, low expression—grey line