Table 2.
Knowledge base for curation and treatment decision
| Databases | Primary institute | Variant | Treatment | Clinical trials | URL |
|---|---|---|---|---|---|
| COSMIC | Wellcome Trust Sanger Institute | Somatic | http://cancer.sanger.ac.uk/cosmic | ||
| ClinVar | National Center for Biotechnology Information (NCBI) | All variants | http://www.ncbi.nlm.nih.gov/clinvar/ | ||
| ClinGen Knowledge Base | ClinGen | All variants | https://www.clinicalgenome.org/resources-tools/ | ||
| Cancer Genome Interpreter (CGI) | Institute for Research in Biomedicine, Barcelona, Spain | Somatic | Yes | https://www.cancergenomeinterpreter.org/home | |
| Clinical Interpretation of Variants in Cancer (CIViC) | Washington University School of Medicine (WashU) | All variants | Yes | http://www.civicdb.org | |
| JAX Clinical Knowledgebase (JAX-CKB) | The Jackson Laboratory | Somatic | Yes | Yes | https://ckb.jax.org/ |
| OncoKB | Memorial Sloan Kettering Cancer Center | Somatic | Yes | http://oncokb.org/#/ | |
| Precision Medicine Knowledgebase (PMKB) | Weill Cornell Medical College | Somatic | https://pmkb.weill.cornell.edu/ | ||
| Cancer Driver Log (CanDL) | Ohio State University (OSU)/James Cancer Hospital | Somatic | Yes | https://candl.osu.edu/ | |
| My Cancer Genome | Vanderbilt University | Somatic | Yes | Yes | https://www.mycancergenome.org/ |
| DoCM | Washington University | All variants | http://docm.info | ||
| Personalized Cancer Therapy Database | MD Anderson Cancer Center | Somatic | Yes | Yes | https://pct.mdanderson.org |