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. 2019 Feb 11;36(3):49. doi: 10.1007/s11095-019-2578-7

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© The Author(s) 2019

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 6 — Effect of niacinamide and 1-methyl-niacinamide on vasorelaxation. Isolated porcine subcutaneous arteries were preconstricted with U46619 (1 μM) followed by stimulation with niacinamide or 1-methyl-niacinamide in cumulatively increasing concentrations. (a) Representative recordings of contractile force during preconstriction (arrow indicates time for addition of U46619) and stimulation with niacinamide or 1-methyl-niacinamide. (b) Vasorelaxation is given as a percentage between preconstricted tone (0% vasorelaxation) and baseline tone (100% vasorelaxation). Data are mean ± SEM for six animals (niacinamide) and two animals (1-methyl-niacinamide). For each animal, data from 2–4 vessel segments with each compound were averaged. CI, confidence interval; EC₅₀, half-maximum effective concentration.