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. 2019 Feb 11;36(3):49. doi: 10.1007/s11095-019-2578-7

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© The Author(s) 2019

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 8 — LASCA and LDI of skin perfusion in pigs after subcutaneous administration of saline, niacinamide and prostaglandin formulations. (a) LASCA perfusion recordings for each of the three formulations (also see supplementary video of LASCA). (b) LASCA AUC calculations during the 0–15 min interval. n=4; *p≤0.05; ****p≤0.00001. (c) Normalized LDI profiles presented as mean±SEM, n=4. (d) Comparison of perfusion between niacinamide and saline 6.53 min after injection presented as mean±SD, n=4; p<0.02. AUC, area under the curve; LASCA, laser speckle contrast analysis; LDI, Laser Doppler imaging; SD, standard deviation; SEM, standard error of the mean.