Table 2.

Three-gene model input (fitness parameters) and results, with and without application of Assumption 2.3

${\widehat{\gamma }}^{\text{ind}}$	${\pi }_{\text{sel}}^{\text{ind}}(\widehat{\theta })$	${\widehat{\gamma }}^{\text{gen}}$	${\pi }_{\text{sel}}^{\text{gen}}(\widehat{\theta })$
(1.040400, 1.020000,	(0.099859, 0.000256,	(1.018, 1.007,	(0.143176, 0.011395,
1.020000, 1.000000,	0.002181, 0.000143,	1.009, 1.000,	0.009522, 0.056227,
1.057046, 1.036320,	0.877841, 0.000756,	1.026, 1.027,	0.685888, 0.033098,
1.036320, 1.016000)	0.018654, 0.000311)	1.019, 1.004)	0.036405, 0.024289)

Here, and for the single-gene results in Table 1, $p_l$, $q_l$ and n are fixed at the values ${\overline{p}}_l$, ${\overline{q}}_l$ and $\overline{n}$ given in Table 5, where the prior settings for the fitness parameters can also be found. The values of ${}_{0}N$ (${}_0ϵ$) and ${}_{1}N$ (${}_1ϵ$) required for the three-gene runs are as in Table 6. We obtain the distances $d{(}_1\widehat{\pi }$,${\pi }_{\text{sel}}^{\text{ind}}(\widehat{\theta }))=0.290$ and $d{(}_1\widehat{\pi }$,${\pi }_{\text{sel}}^{\text{gen}}(\widehat{\theta })=0.067$; since ${}_1ϵ=0.112$, we reject the independence assumption