A robust two-compartment model with dose- and time-independent pharmacokinetic parameters was developed to characterize the disposition of risankizumab, an anti-interleukin-23 monoclonal antibody, in subjects with plaque psoriasis and Crohn’s disease.

Of the factors evaluated (demographics, disease population, laboratory values, and anti-drug antibody development), only body weight and baseline albumin level were statistically correlated with risankizumab clearance. Body weight had a modest effect on risankizumab exposure while albumin had no meaningful impact.

After accounting for differences in body weight and baseline albumin levels between psoriasis and Crohn’s disease patient populations, no significant differences in the pharmacokinetics of risankizumab were found between the populations.