Fig. 6.

Predictions of 4-year hazard and survival for experiencing a first relapse in patients with 1 relapse in the previous 12 months, together with predictions of 4-year EDSS time-course for the typical subject. The lines represent predictions from the model for a the hazard, b survival (fraction relapse-free patients), and c EDSS progression over 4 years following treatment according to five treatment sequences: (1) 4 years of placebo (red); (2) 4 years of Cladribine Tablets, 7 mg/kg cumulative dose (brown dashes); (3) 2 years of Cladribine Tablets followed by 2 years of placebo, 3.5 mg/kg cumulative dose—represents the recommended treatment sequence (green); (4) 2 years of placebo followed by 2 years of Cladribine Tablets, 3.5 mg/kg cumulative dose (blue dashes); and (5) 2 years of Cladribine Tablets followed by 2 years of placebo, 5.25 mg/kg cumulative dose (purple). EDSS Expanded Disability Status Scale.

Adapted from Novakovic et al. [39]. © The American College of Clinical Pharmacology 2018