Table I.

Process Temperatures and Formulation Compositions for the Hot-Melt Extruded Formulations as well as Subsequently Applied Temperatures During the Printing Step

Formulation	Drug	Polymer(s)	Plasticizer	HME T (°C)	Print T (°C)
1	30%	50% HPC EF + 20% HPMC E5		150	185
2	30%	70% PEO N80		140	185
3	30%	65% HPC EF + 5% PEO N80		140	190
4	30%	60% HPMC E5 + 10% PEO N80		140	–
5	30%	40% HPC EF + 30% PEO N80		140	195
6	30%	40% HPMC K100 + 20% PEO N80	10% TPGS	120	–
7	30%	40% HPMC K100 + 30% PEO N750		155	–
8	30%	45% HPC HF + 25% PEO N750		130	185*
9	30%	20% RS PO + 20% RL PO +30% PEO N750		140	–
10	30%	60% HPC EF + 10% PEO N80		130	185
11	30%	20% RS PO + 20% RL PO +27.5% PEO N750	2.5% TEC	100	165
12	30%	40% HPC HF + 30% L100		130	170
13	30%	40% HPC HF + 30% E PO		130	175

HME hot-melt extrusion, T temperature

*Formulation 8 showed day-to-day variability regarding the printability and should therefore be considered as non-printable