Table IV.
Drug Content (%) for 3D-Printed Tablets (Different Sizes and Infill Levels) as well as Hot-Melt Extruded Filaments That Served as Starting Material in the Printing Process
| % API in 3D-printed tablets and hot-melt extruded filament (w/w) | |||||||
|---|---|---|---|---|---|---|---|
| 6 mm, 15% | 6 mm, 90% | 8 mm, 15% | 8 mm, 90% | 10 mm, 15% | 10 mm, 90% | Filament | |
| 1 | 31.6 ± 0.2 | 28.0 ± 1.7 | 30.4 ± 0.2 | 31.2 ± 1.4 | 27.5 ± 1.1 | 29.9 ± 1.3 | 27.9 ± 2.6 |
| 2 | 30.6 ± 0.3 | 30.8 ± 0.1 | 30.1 ± 0.7 | 30.9 ± 0.0 | 30.4 ± 0.1 | 30.6 ± 0.1 | 30.2 ± 1.0 |
| 3 | 31.0 ± 0.1 | 30.9 ± 0.1 | 31.1 ± 0.1 | 31.0 ± 0.0 | 30.9 ± 0.1 | 30.7 ± 0.1 | 31.7 ± 0.2 |
| 5 | 30.3 ± 0.5 | 30.5 ± 0.1 | 30.6 ± 0.2 | 30.8 ± 0.0 | 31.3 ± 0.0 | 30.7 ± 0.1 | 29.6 ± 1.2 |
| 10 | 34.7 ± 0.2 | 34.6 ± 0.1 | 32.8 ± 0.4 | 33.4 ± 0.4 | 34.3 ± 0.1 | 30.4 ± 0.4 | 31.3 ± 1.8 |
| 11 | 31.8 ± 0.1 | 32.1 ± 0.1 | 31.6 ± 0.0 | 30.9 ± 0.0 | 31.2 ± 0.1 | 31.0 ± 0.1 | 31.0 ± 0.3 |
| 12 | 30.2 ± 0.4 | 30.9 ± 0.1 | 31.1 ± 0.1 | 30.3 ± 0.0 | 30.4 ± 0.1 | 30.7 ± 0.1 | 29.7 ± 1.1 |
| 13 | 31.1 ± 0.1 | 30.8 ± 0.3 | 30.8 ± 0.1 | 30.8 ± 0.2 | 30.9 ± 0.0 | 30.3 ± 0.1 | 30.2 ± 0.6 |
The theoretical drug content for all formulations was 30% (w/w). Data presented as mean ± SD, n = 3 for the 3D-printed tablets and n = 10 for the HME filaments