Table VI.

PK Parameters of ZgI (i.v and p.o) and ZgI-SMEDDS (p.o) ($\overline{x}$ ± S, n = 6)

PK parameters	Units	i.v ZgI	ig (intragastrical administration)
			ZgI	ZgI-SMEDDS
Dose	mg/kg	2	10	10
Vd	L/kg	189.34 ± 36.47	2983.4 ± 289.27	1214.69 ± 143.57*
CL	L min−1 kg−1	8.37 ± 1.05	91.51 ± 11.28	25.87 ± 3.56*
AUC0-t	ng min mL−1	246.55 ± 28.43	78.12 ± 12.46	270.52 ± 37.18*
MRT	h	5.42 ± 0.65	3.26 ± 0.18	6.55 ± 0.26*
Cmax	ng mL−1	127.3 ± 26.87	8.75 ± 1.21	65.95 ± 8.74
T1/2	h	12.67 ± 1.33	19.32 ± 4.75	19.2 ± 5.21*
Tmax	h	0.01	0.25	1
F	%	–	3.16 ± 0.89	21.94 ± 4.67

Compared with the ZgI group, *P < 0.05, **P < 0.01. i.v intravenous