Table 1.
Patient, Tumor, and iPSC Line Information
| Patient Information |
Tumor Information |
iPSC Lines Generated |
||||||
|---|---|---|---|---|---|---|---|---|
| Patient ID | Sex | Age (at PNF Resection) | NF1 Germline Mutation | Tumor ID | Diagnostic | NF1 Somatic Mutation | iPSC Line (Named in the Paper) | iPSC Line (Banking Name) |
| 3 | XX | 8 | c.3943C > T; p.Gln1315∗ | 3PNF | PNF with diffuse extraneural invasion | LOH (HR) whole ch.17q |
3PNFiPS(NF1+/−) | 3PNF_FiPSsv_PM |
| 3PNFiPS(NF1−/−) | 3PNF_SiPSsv_MM | |||||||
| 5 | XY | 10 | intragenic deletion (E16-35) | 5PNF | PNF with diffuse extraneural invasion | LOH (3.8Mb del) | 5PNFiPS(NF1+/−) | 5PNF_TDiPSsv_PM |
| 5PNFiPS(NF1−/−) | 5PNF_TDiPSsv_MM | |||||||
| 6 | XX | 33 | c.2946delT; p.Leu983∗ | 6PNF | PNF with diffuse extraneural invasion | c.2033dupC; p.Ile679Aspfs∗21 | 6PNFiPS(NF1+/−) | 6PNF_SiPSrv_PM |
| 7 | XX | 66 | c.2033dupC; p.Ile679Aspfs∗21 | 7PNF | PNF with diffuse extraneural invasion | LOH (1.4Mb del) | 7PNFiPS(NF1+/−) | 7PNF_TDiPSrv_PM |
| 13 | XY | 14 | c.1318C > T; p.Arg440∗ | 13PNF | PNF with diffuse extraneural invasion | LOH (HR) whole ch.17q |
13PNFiPS(NF1+/−) | not banked |
LOH, loss of heterozygosity; HR, homologous recombination. The link below will take you to the Spanish National Stem Cell Bank-Institute of Health Carlos III, where the iPSC lines have been deposited to be able to be distributed. http://www.eng.isciii.es/ISCIII/es/contenidos/fd-el-instituto/fd-organizacion/fd-estructura-directiva/fd-subdireccion-general-investigacion-terapia-celular-medicina-regenerativa/fd-centros-unidades/fd-banco-nacional-lineas-celulares/fd-lineas-celulares-disponibles/lineas-de-celulas-iPS.shtml.