TABLE 4.
Effect of the MTHFR 677C→T polymorphism1
| Genotype | ||||
|---|---|---|---|---|
| CC (n = 742) | CT (n = 716) | TT (n = 198) | P 2 | |
| Serum folate, nmol/L | 34.7 ± 18.0 | 33.3 ± 17.2 | 28.6 ± 19.7 | <0.0001 |
| Red blood cell folate, nmol/L | 1085 ± 427 | 1046 ± 416 | 898 ± 437 | <0.0001 |
| Total homocysteine, µmol/L | 8.3 ± 2.1 | 8.6 ± 2.9 | 10.6 ± 5.8 | <0.0001 |
| Formate, µmol/L | 26.6 ± 7.3 | 25.8 ± 7.7 | 24.1 ± 9.0 | <0.0001 |
1Values are means ± SDs. MTHFR, methylenetetrahydrofolate reductase.
2One-factor ANOVA was used to determine differences in metabolite concentrations by MTHFR 677C→G genotype.