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. Author manuscript; available in PMC: 2019 Feb 13.
Published in final edited form as: Dig Dis Sci. 2018 Jul 24;63(11):2910–2922. doi: 10.1007/s10620-018-5216-z

Fig. 1.

Fig. 1

Pattern of daily body weight changes and daily clinical illness scores of GPR35+/+ and GPR35−/− mice receiving DSS. Colitis was induced by administration of 4% (w/v) DSS in drinking water for 5 consecutive days in GPR35−/− mice and GPR35+/+ mice, followed by administration of regular facility water for 1 day as previously described [21, 22]. a The percentage of daily animal body weight changes during the experimental period. A significant difference in body weight loss across the strains was observed only on day 6 (*p < 0.05 vs. GPR35+/+ + DSS). b Summary of daily clinical illness scores during the experimental period. The severity of daily clinical changes was scored in each mouse based on weight loss, stool consistency, and presence of occult or gross blood. After DSS administration, the daily clinical illness scores of the GPR35−/− mice were augmented significantly on days 1, 2, 5, and 6 as compared with the GPR35+/+ mice. N = 10 (GPR35+/+ + DSS), n = 8 (GPR35−/− + DSS); *p < 0.05 versus GPR35+/+ + DSS