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. Author manuscript; available in PMC: 2019 Aug 1.
Published in final edited form as: J Mol Cell Cardiol. 2018 Jun 7;121:51–59. doi: 10.1016/j.yjmcc.2018.06.002

Figure 6. PKA can inhibit PLCε in COS-7 cells downstream of all activators, however, PKG only inhibits Rho-dependent activation.

Figure 6

COS-7 cells were Cotransfected with PLCε and Gβγ (A and E), Rho (B and F), H-Ras G12V (C and G), Rap1 (D and H), and PKA catalytic subunit (A,B,C and D) or constitutively active PKG (E,F,G and H). Total IP production was measured 48 hours after transfection as indicated in Materials and Methods. Data was generated from at least 3 experiments analyzed by two way unpaired ANOVA with Sidak’s post-hoc test. *** p<0.0001 **** p<0.00001.