Flowchart for the diagnosis of CeH. CeH, central hypothyroidism; COS, controlled ovarian stimulation; ES, empty sella; IO, iron overload or hemochromatosis; MPHD, multiple pituitary hormone defect; MRI, magnetic resonance imaging; PID, pituitary infiltrative disease; PSI, pituitary stalk interruption; rhGH, recombinant human growth hormone; TBI, traumatic brain injury; VA, vascular accident.