Table 4.

Conditions requiring a reevaluation and possible adjustment of the replacement therapy.

Conditions at risk of an uptitration of L-T4 therapy

Delay in psychomotor and cognitive development in infants and children

Introduction of GH replacement therapy

Introduction of estrogen replacement therapy or oral contraceptive

Pubertal development

Controlled ovarian stimulation

Pregnancy

Weight gain

Introduction of therapies affecting levothyroxine metabolism or absorption

Conditions at risk of a downtitration of L-T4 therapy

Cardiovascular comorbidities

Delivery

Menopause

Weight loss

Discontinuation of GH or estrogen therapies or treatments affecting levothyroxine metabolism or absorption