Comparison 5. Sensitivity analysis 1: Studies at low risk of bias.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Comparison 1 ‐ All‐cause mortality	2	6179	Risk Ratio (M‐H, Fixed, 95% CI)	1.01 [0.81, 1.26]
2 Comparison 1 ‐ Quality of life	2	1998	Mean Difference (IV, Fixed, 95% CI)	0.09 [‐1.86, 2.05]
3 Comparison 1 ‐ AMI incidence	1	2604	Risk Ratio (M‐H, Random, 95% CI)	0.94 [0.73, 1.20]
4 Comparison 1 ‐ Need for revascularisation procedure	1	2604	Risk Ratio (M‐H, Fixed, 95% CI)	0.98 [0.82, 1.18]
5 Comparison 2 ‐ AMI incidence	1	2604	Risk Ratio (M‐H, Fixed, 95% CI)	0.94 [0.73, 1.20]
6 Comparison 3 ‐ All‐cause mortality	2	1488	Risk Ratio (M‐H, Fixed, 95% CI)	0.80 [0.22, 2.95]
7 Comparison 3 ‐ Quality of life	2	975	Std. Mean Difference (IV, Random, 95% CI)	0.30 [‐0.13, 0.73]
8 Comparison 3 ‐ AMI incidence (fatal)	1	944	Risk Ratio (M‐H, Fixed, 95% CI)	5.04 [0.24, 104.75]
9 Comparison 3 ‐ AMI incidence (non‐fatal)	1	944	Risk Ratio (M‐H, Fixed, 95% CI)	0.34 [0.04, 3.22]
10 Comparison 3 ‐ Angina episodes frequency	2	1446	Mean Difference (IV, Fixed, 95% CI)	‐0.64 [‐0.96, ‐0.32]
11 Comparison 3 ‐ Adverse events incidence	2	1488	Risk Ratio (M‐H, Fixed, 95% CI)	1.28 [1.06, 1.53]
12 Comparison 4 ‐ Quality of life	3	1005	Std. Mean Difference (IV, Random, 95% CI)	0.54 [‐0.03, 1.10]
12.1 Macrovascular angina	2	975	Std. Mean Difference (IV, Random, 95% CI)	0.30 [‐0.13, 0.73]
12.2 Microvascular angina	1	30	Std. Mean Difference (IV, Random, 95% CI)	1.13 [0.36, 1.91]
13 Comparison 4 ‐ Time to 1‐mm ST‐segment depression	2		Mean Difference (Fixed, 95% CI)	34.62 [33.08, 36.16]