Comparison 6. Sensitivity analysis 2: Exchange of model for data synthesis.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Comparison 1 ‐ All‐cause mortality	3	6249	Risk Ratio (M‐H, Random, 95% CI)	1.00 [0.81, 1.25]
2 Comparison 1 ‐ Quality of life	3	2254	Mean Difference (IV, Random, 95% CI)	0.28 [‐1.57, 2.13]
3 Comparison 1 ‐ AMI incidence	2	2674	Risk Ratio (M‐H, Fixed, 95% CI)	0.88 [0.69, 1.13]
4 Comparison 1 ‐ Need for revascularisation procedure	2	2674	Risk Ratio (M‐H, Random, 95% CI)	0.98 [0.82, 1.18]
5 Comparison 1 ‐ Adverse events incidence	2	638	Risk Ratio (M‐H, Random, 95% CI)	1.34 [0.90, 1.99]
6 Comparison 2 ‐ AMI incidence	3	2983	Risk Ratio (M‐H, Random, 95% CI)	0.56 [0.19, 1.63]
7 Comparison 2 ‐ Angina episodes frequency	2	402	Mean Difference (IV, Random, 95% CI)	0.08 [‐0.85, 1.01]
8 Comparison 2 ‐ Adverse events incidence	3	947	Risk Ratio (M‐H, Random, 95% CI)	1.50 [1.12, 2.01]
8.1 Macrovascular angina	2	691	Risk Ratio (M‐H, Random, 95% CI)	1.53 [1.13, 2.07]
8.2 Microvascular angina	1	256	Risk Ratio (M‐H, Random, 95% CI)	1.17 [0.40, 3.38]
9 Comparison 3 ‐ All‐cause mortality	3	2053	Risk Ratio (M‐H, Random, 95% CI)	0.87 [0.25, 3.04]
10 Comparison 3 ‐ Quality of life	3	1533	Std. Mean Difference (IV, Fixed, 95% CI)	0.11 [0.01, 0.22]
11 Comparison 3 ‐ AMI incidence (fatal)	2	1509	Risk Ratio (M‐H, Random, 95% CI)	1.37 [0.10, 19.46]
12 Comparison 3 ‐ AMI incidence (non‐fatal)	2	1509	Risk Ratio (M‐H, Random, 95% CI)	0.41 [0.08, 2.11]
13 Comparison 3 ‐ Angina episodes frequency	3	2004	Mean Difference (IV, Random, 95% CI)	‐0.78 [‐1.28, ‐0.27]
14 Comparison 3 ‐ Adverse events incidence	3	2053	Risk Ratio (M‐H, Random, 95% CI)	1.21 [1.06, 1.39]
15 Comparison 4 ‐ Quality of life	4	1563	Std. Mean Difference (IV, Fixed, 95% CI)	0.13 [0.03, 0.23]
15.1 Macrovascular angina	3	1533	Std. Mean Difference (IV, Fixed, 95% CI)	0.11 [0.01, 0.22]
15.2 Microvascular angina	1	30	Std. Mean Difference (IV, Fixed, 95% CI)	1.13 [0.36, 1.91]
16 Comparison 4 ‐ Time to 1‐mm ST‐segment depression	3		Mean Difference (Random, 95% CI)	51.05 [4.05, 98.04]