Martinez 2017.

Trial name or title	Prophylactic melatonin for delirium in intensive care (Pro‐MEDIC): study protocol for a randomised controlled trial. Country: Australia
Methods	Multicentre, randomized double‐blind placebo‐controlled trial
Participants	Adult ICU patient with a ICU LOS of minimum 72 hours of admission. Expected: 850 adult ICU patients
Interventions	Interventions 4 mg melatonin enterally at 21:00 every day from enrolment until 14 days or to ICU discharge, whichever comes first Control Placebo tablet
Outcomes	Proportion of delirium‐free assessments Overall prevalence of delirium Duration of delirium Severity of delirium Sleep quality ICU and hospital length of stay Morbidity and mortality (28/90 days) Healthcare costs CAM‐ICU will be used as measurement of delirium.
Starting date	Trial registered 20 December 2015
Contact information	ed.martinez@hnehealth.nsw.gov.au
Notes	Study number: ACTRN12616000436471 Status: Recruiting Contact with author: email sent 5 July 2017 for status ‐ awaiting response from corresponding author