Nedergaard 2016.

Trial name or title	Non‐sedation versus sedation with a daily wake‐up trial in critically ill patients receiving mechanical ventilation ‐ effects on long‐term cognitive function: Study protocol for a randomised controlled trial, a sub study of the NONSEDA trial Country: Denmark
Methods	Randomized clinical parallel group superiority trial (sub‐study of a multinational study see Toft 2014)
Participants	Adult ICU patients intubated and expected to be mechanically ventilated more than 24 hours; expected n = 200
Interventions	Intervention Non‐sedation supplemented with pain management during mechanical ventilation Control Sedation with daily wake‐up attempt
Outcomes	Cognitive function 3 months after discharge 7 specific cognitive tests at 3 months after discharge and the association between hypoactive and agitated delirium during ICU admission and long‐term cognitive function
Starting date	January 2014
Contact information	Helene Nedergaard (helene.korvenius.nedergaard@rsyd.dk), Department of Anesthesiology and Intensive Care, Lillebaelt Hospital,Skovvangen 2‐8, DK‐6000 Kolding, Denmark
Notes	Study number: NCT02035436 Status: 25 September 2016, 535 of 700 were included. Contact with Authors: emailed 26 September 2016 ‐ Author responded that the NONSEDA‐trail was still recruiting.