Nickels 2017.

Trial name or title	Critical care cycling study (CYLIST) trial Study protocol for a randomized controlled trial of usual care plus additional in‐bed cycling sessions versus usual care in the critically ill Country: Australia
Methods	2‐arm parallel randomized controlled trial
Participants	Adults, expected to require more than 48 hours of mechanical ventilation, expected n = 68
Interventions	Intervention Usual physiotherapy and 30 minutes daily progressive lower limb in‐bed cycling with a bedside cycle ergometer. Resistance applied by the cycle ergometer will be adjusted to facilitate patient intensity between 3 to 5 on the Borg scale of perceived exertion. Control Usual physiotherapy
Outcomes	Reduction in rate of rectus femoralis cross‐sectional area atrophy and ICU‐acquired weakness (muscle morphology and muscle strength) Physical function (ICU mobility scale, Functional Status Score for the Intensive Care Unit (FSS‐ICU), Functional milestones, 6 min walk test, CAM‐ICU. QoL The 5‐level EQ‐5D version (EQ‐5D‐5L), Intervention acceptability (customized questionnaires)
Starting date	Unclear
Contact information	Corresponding author: marc.nickles@health.qld.gov.au
Notes	Funding: no external sponsors. Study number: ACTRN12616000948493 Status: unknown Contact with authors: email sent on 1 May 2018 and study author responded that they expected to have finalized recruitment end of May 2018.