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. 2018 Feb 16;29(3):1090–1108. doi: 10.1093/cercor/bhy015

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Figure 7. — Loss of Hcrt innervation does not affect sleep parameters related to sleep homeostasis or c-FOS expression in cortical nNOS/NK1R neurons. (A) Immunohistochemical analysis of c-FOS and cortical nNOS/NK1R neurons from adult Ox-tTA;DTA (DTA) mice and monogenic controls (MC) implanted for EEG (scale bar = 50 μm). (B) Neither NREM delta energy (NRDE; left panel) recorded during a 2 h recovery sleep (RS) period after a 4 h sleep deprivation (SD), nor the proportion of c-FOS+ cortical nNOS neurons (right panel) differed between the 2 mouse strains. For NRDE, 2-way ANOVA revealed a significant main effect of “sleep condition” (F(1,14) =21.30, P = 0.0003) without a significant effect of genotype or a genotype x condition interaction. Sleep condition was also significant for c-FOS colocalization in cortical nNOS neurons (F(1,14) = 274.71, P = 0.0001) without an effect of genotype or an interaction; [Sleep deprivation, SD; Recovery sleep, RS].