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. Author manuscript; available in PMC: 2019 Nov 28.
Published in final edited form as: J Am Chem Soc. 2018 Nov 12;140(47):16115–16123. doi: 10.1021/jacs.8b08416

Table 1.

Steady state incorporation kinetic data

5’- d(ACAACTTTAACTCACACAATGTA)
3’-d(GAGCTCATGTTGAAATTGAGTGTGTTACAT-Y-TCTAGTGCCGTCTGTTTGTTTTCTTACCTTAG)
Y dXTP kcat (min−1) KM (μM) kcat/Km
(M−1 min−1)
A dTTP 5.1 ± 0.7 0.05 ± 0.02 1.2 × 108
TPT3 dNaMTPa 10.7 ± 0.4 0.09 ± 0.01 1.3 × 108
dPTMOTP 19.4 ± 1.2 0.08 ± 0.03 2.9 × 108
dMTMOTP 8.5 ± 1.7 0.22 ± 0.10 4.2 × 107
a

Reproduced from Morris et al.7