Table 4.
Diagnostic of Diploid Cell Cycle Parameter Values to Discriminate Cases from Control
| Diagnostic | Parameter | Cutoff value (%) | Sensitivity (95% CI) | Specificity (95% CI) | PPV | NPV | AUC | Z value | p value |
|---|---|---|---|---|---|---|---|---|---|
| Control vs. LSIL | Dip G1 | ≤91.6 | 50 (18.9-81.1) | 87.10 (70.1-96.3) | 55.6 | 84.4 | 0.682 | 2.00 | 0.046 |
| Dip G2 | >0.17 | 50 (18.9-81.1) | 74.19 (55.4-88.1) | 38.5 | 82.1 | 0.566 | 0.62 | 0.538 | |
| Dip S | >7.81 | 50 (18.9-81.1) | 87.10 (70.1-96.3) | 55.6 | 84.4 | 0.673 | 1.66 | 0.098 | |
| Control vs. HSIL | Dip G1 | ≤81.49 | 65 (40.8-84.5) | 100.00 (88.7-100) | 100.0 | 81.6 | 0.792 | 4.69 | <0.001 |
| Dip G2 | ≤0 | 85 (62.1-96.6) | 41.94 (24.6-60.9) | 48.6 | 81.3 | 0.628 | 1.63 | 0.104 | |
| Dip S | >8.93 | 70 (45.7-88.0) | 100.00 (88.7-100) | 100.0 | 83.8 | 0.802 | 4.50 | <0.001 | |
| Control vs. SCC | Dip G1 | ≤90.14 | 78.57 (49.2-95.1) | 96.77 (83.2-99.5) | 91.7 | 90.9 | 0.866 | 6.90 | <0.001 |
| Dip G2 | >2.07 | 14.29 (2.2-42.8) | 100.00 (88.7-100) | 100.0 | 72.1 | 0.464 | 0.39 | 0.701 | |
| Dip S | >8.93 | 71.43 (41.9-91.4) | 100.00 (88.7-100) | 100.0 | 88.6 | 0.811 | 4.08 | <0.001 | |
| Control vs. Cases (LSIL +HSIL + SCC) | Dip G1 | ≤88.48 | 59.09 (43.3-73.7) | 100.00 (88.7-100) | 100.0 | 63.3 | 0.791 | 5.26 | <0.001 |
| Dip G2 | ≤0 | 72.73 (57.2-85.0) | 41.94 (24.6-60.9) | 64.0 | 52.0 | 0.555 | 0.80 | 0.422 | |
| Dip S | >8.93 | 61.36 (45.5-75.6) | 100.00 (88.7-100) | 100 | 64.6 | 0.775 | 5.19 | <0.001 |