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The dollar cost and runtime on Amazon Web Services for running a 4-step pipeline on a whole genome using GATK 4 versus elPrep 4. While GATK 4 is able to run on a wider range of Amazon instances, the overall runtime is much larger compared to elPrep 4. The fastest run with GATK 4 takes over 17.5 hours on m5.12xlarge and costs 48.71$, whereas the elPrep 4 run takes a bit less than 3 hours and costs only 16.25$ on m5.24xlarge, being almost 6x faster for 3x less money.
