Table 1. Echocardiographic and hemodynamic measures in the Sham and TAC groups.
| WT-Sham | Sirt5 KO-Sham | WT-TAC | Sirt5 KO-TAC | |
|---|---|---|---|---|
| n = 6 | n = 7 | n = 9 | n = 10 | |
| Heart Rate (bpm) | 547.5 ± 11.08 | 523 ± 21.85 | 516.11 ± 10.92 | 504.7 ± 16.29 |
| Peak flow velocity (mm/s) | 790.19 ± 50.07 | 845.86 ± 33.43 | 3414.65 ± 5.96### | 3386.51 ± 29.80+++ |
| LVAWTd (mm) | 0.92 ± 0.05 | 0.98 ± 0.05 | 1.45 ± 0.06### | 1.34 ± 0.05+++ |
| LVAWTs (mm) | 1.33 ± 0.05 | 1.44 ± 0.05 | 1.89 ± 0.05### | 1.80 ± 0.06+++ |
| LVPWTd (mm) | 0.8 ± 0.06 | 0.83 ± 0.06 | 1.36 ± 0.06### | 1.35 ± 0.05+++ |
| LVPWTs (mm) | 1.28 ± 0.06 | 1.19 ± 0.11 | 1.73 ± 0.09## | 1.53 ± 0.06+ |
| LVIDd (mm) | 3.96 ± 0.06 | 4.03 ± 0.05 | 4.22 ± 0.10 | 3.92 ± 0.06* |
| LVIDs (mm) | 2.77 ± 0.09 | 2.86 ± 0.06 | 3.26 ± 0.15# | 2.73 ± 0.10** |
| LVEDV (μl) | 68.71 ± 2.44 | 71.46 ± 2.03 | 80.28 ± 4.66 | 67.10 ± 2.55* |
| LVESV (μl) | 28.92 ± 2.34 | 31.28 ± 1.66 | 44.08 ± 5.27# | 28.28 ± 2.55* |
| Stroke Volume (μl) | 39.79 ± 2.40 | 40.68 ± 1.24 | 36.21 ± 2.30 | 38.82 ± 0.98 |
| LVEF (%) | 57.92 ± 2.95 | 56.33 ± 1.59 | 46.07 ± 3.45# | 58.52 ± 2.44* |
| LVFS (%) | 30.27 ± 2.02 | 29.11 ± 1.06 | 23.01 ± 2.01# | 30.69 ± 1.67* |
| LV Mass Corrected (mg) | 101.30 ± 7.63 | 108.40 ± 5.33 | 218.69 ± 13.59### | 165.99 ± 9.11***/+++ |
LVAWTd = left ventricular diastolic anterior wall thickness; LVAWTs = left ventricular systolic anterior wall thickness; LVPWTd = left ventricular diastolic posterior wall thickness; LVPWTs = left ventricular systolic posterior wall thickness; LVIDd = left ventricular internal diastolic diameter; LVIDs = left ventricular internal systolic diameter; LVEDV = left ventricular end-diastolic volume; LVESV = left ventricular end-systolic volume; LVEF = left ventricular ejection fraction; LVFS = left ventricular shortening fraction. All data are shown as mean ± S.E.M.
#denotes the P < 0.05
##denotes the P < 0.01 and
###denotes the P < 0.001 for the comparisons between WT-Sham and WT-TAC groups.
+denotes the P < 0.05 and
+++denotes the P < 0.001 for the comparisons between Sirt5 KO-Sham and Sirt5 KO-TAC groups.
*denotes the P < 0.05
**denotes the P < 0.01 and
***denotes the P < 0.001 for the comparisons between WT-TAC and Sirt5 KO-TAC groups.