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. 2019 Feb 13;14(2):e0211820. doi: 10.1371/journal.pone.0211820

Table 2. Non-insulin diabetes treatment use before and after insulin initiation.

Treatment Use 90 days Before 90 days After Continuation (%) a
Overall, n 65,902 55,839 b 84.7

Drug class, n (%)
     Metformin 47,846 (72.6) 40,468 (72.5) 84.6
     Sulfonylurea 22,834 (34.6) 16,815 (30.1) 73.6
     Dipeptidyl peptidase 4 inhibitor 7,673 (11.6) 6,006 (10.8) 78.3
     Glucagon-like peptide-1 receptor agonist 5,512 (8.4) 4,288 (7.7) 77.8
     Sodium glucose co-transporter inhibitor 1,047 (1.6) 857 (1.5) 81.9
     Thiazolidinedione 6,789 (10.3) 5,386 (9.6) 79.3

a: Continuation (%) was defined as the indicated medication class was used both before and after insulin initiation.

b: Among participants who were continuously enrolled for 90 days after initiating insulin (n = 65,902), the majority of them had refilled at least one non-insulin diabetes medication during the 90 days after insulin initiation (n = 55,839). Prevalence (%) after insulin initiation was defined as the proportion of participants used the indicated medication class among those who were continuously enrolled and used any non-insulin diabetes medications after insulin initiation (denominator n = 55,839).