Table 3. Reference intervals for active VWF and other VWF parameters in 120 healthy individuals.
| Parameter | Mean | SD | %CV | Median | IQR | Ref. interval 2.5%-97.5% | Min | Max |
|---|---|---|---|---|---|---|---|---|
| VWF:Act (%) | 115.4 | 17.4 | 15.1 | 112.9 | 25.1 | 91.6–154.8 | 91.0 | 167.9 |
| VWF:Ag (%) | 115.1 | 32.2 | 28.0 | 104.5 | 39.8 | 65.1–189.9 | 40.0 | 218.0 |
| VWF:RCo (%) | 103.9 | 32.9 | 31.7 | 102.6 | 48.1 | 47.0–161.5 | 20.8 | 243.4 |
| VWF:GP1bM (%) | 112.9 | 32.9 | 29.1 | 110.6 | 43.1 | 58.3–189.7 | 41.3 | 229.5 |
| VWFpp (%) | 121.8 | 23.1 | 24.1 | 121.2 | 32.1 | 73.3–188.7 | 60.3 | 210.3 |
| Plt:VWF (%) | 6.9 | 3.2 | 46.4 | 6.4 | 3.8 | 1.4–15.6 | 0.9 | 18.0 |
%CV, inter-individual variation expressed as coefficient of variation, calculated as (SD/Mean)*100; IQR, interquartile range, calculated as 75th– 25th percentile; Ref. interval, reference interval, calculated as the 2.5th percentile to the 97.5th percentile of the distribution; VWF:Act, active VWF, % of level in NPP. VWF:Ag, VWF antigen; VWF:RCo, VWF ristocetin cofactor activity; VWF:GP1bM, VWF binding to gain-of-function GP1b fragments; VWFpp, VWF propeptide, % of level in NPP; Plt:VWF, platelet-VWF binding, % of signal for beads.