Table 2.
Univariate and Multivariate Analyses of Survival in 50 Patients with Pancreatic Ductal Adenocarcinoma.
| Variable | Number of Cases | Univariate Log-Rank Test P Value | Cox Multivariable Analysis | |
|---|---|---|---|---|
| P Value | HR (95% CI) | |||
| Age, years | .265 | |||
| <59 | 19 | |||
| ≥59 | 31 | |||
| Gender | .648 | |||
| Male | 32 | |||
| Female | 18 | |||
| Tumor location | .890 | |||
| Head | 33 | |||
| Others | 17 | |||
| CA19-9, U/L | .137 | .168 | ||
| <37 | 14 | 1 (reference) | ||
| ≥37 | 36 | 2.852 (0.643-12.648) | ||
| CEA, ng/mL | .887 | |||
| <5 | 30 | |||
| ≥5 | 20 | |||
| TNMa | .819 | |||
| I+II | 47 | |||
| III+IV | 3 | |||
| T stage | .449 | |||
| T1+T2 | 26 | |||
| T3+T4 | 24 | |||
| N stage | .448 | |||
| N0 | 33 | |||
| N1 | 17 | |||
| Differentiation | .943 | |||
| Poor | 14 | |||
| Moderate | 36 | |||
| Tumor size, cmb | .061 | .081 | ||
| <3.35 | 27 | 1 (reference) | ||
| ≧3.35 | 23 | 0.360 (0.115 -1.134) | ||
| Vascular invasion | .054 | .071 | ||
| No | 31 | 1 (reference) | ||
| Yes | 19 | 2.586 (0.920-7.265) | ||
| Surgical marginsc | .867 | |||
| No | 41 | |||
| Yes | 9 | |||
| Adjuvant therapy | .418 | |||
| No | 31 | |||
| Yes | 19 | |||
| MiR-132 | .028 | .044 | ||
| Low | 24 | 1 (reference) | ||
| High | 26 | 0.309 (0.098-0.970) | ||
Abbreviations: CEA, carcinoembryonic antigen; CI, confidence interval; HR, hazard ratio; miR-132, microRNA-132; TNM, tumor node metastasis.
a The seventh edition of the TNM Classification of Malignant Tumors.
b3.35 cm is a mean of tumor diameters.
c Surgical margin free is defined when there was no tumor cell inside 0.5 cm of incisal edge.