Fig 1. Waterfall plot of changes of M-component in response to dara treatment.

The changes in measurable M-component are plotted and grouped according to IMWG treatment response criteria into CR = complete remission, VGPR = very good partial remission, PR = partial remission, MR = minimal response, SD = stable disease and PD = progressive disease. Bacterial and viral infections are shown for nine patients that suffered from infectious complications. VZV = varicella zoster virus, UTI = urinary tract infection, EBV = Epstein-Barr virus, HI = H. Influenza, hMPV = human metapneumovirus, RSV = respiratory syncytial virus, CMV = cytomegalovirus.