Effects of oridonin on the dynamic force spectra for EGF-EGFR complex in KYSE-150 cells. (A) Control KYSE-150 cells, (B) 10 μM oridonin treated KYSE-150 cells,(C) 30 μM oridonin treated KYSE-150 cells, (D) 50 μM oridonin treated KYSE-150 cells, (E) 2.5 μM MNAC and 50 μM oridonin treated KYSE-150 cells, (F) 2.5 μM MNAC treated KYSE-150 cells. Forces were measured at different loading rates by EGF-modified tips and each data point represented the mean value of three independent experiments with about 1000 effective force curves.