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Schematic diagram illustrating the molecular mechanism of oridonin inhibited EGF-EGFR binding and cell death by ROS dependent way in KYSE-150 cells. F, P, xβ, koff and ΔG is the unbinding force, binding probability, energy barrier width, dissociation off-rate constant and activation energy for EGF-EGFR complex on the surface of KYSE-150 cells, respectively.
