Fig 2:

Cardiac index and blood lactate level comparisons between cardiac specific EdnrB homozygous (EdnrB^flox/flox), heterozygous (EdnrB^flox/+) and cre-negative control mice. a) Both EdnrB^flox/flox and EdnrB^flox/+ mice maintains a higher CI under extreme hypoxia of 10% and 5% O₂. b) Lactate levels were significantly lower in EdnrB^flox/+ mice at 10% and 5% O₂ when compared with the cre-negative group and in EdnrB^flox/flox at 5% O₂. The trends were inversely related to the CI where it is high in the cre-negative controls, medium in the EdnrB^flox/flox group and low in the EdnrB^flox/+ group. Error bar indicates ± standard error.