Fig 3:

Cardiac index and blood lactate level comparisons between BQ-788, Bosentan treated and control mice. a) Both Bosentan and BQ-788 treated mice maintains a relative higher CI under extreme hypoxia of 10% and 5% O₂. However, the level in BQ-788 treated mice was significantly higher at 5% O₂ when compared to both Bosentan and control mice. b) Lactate levels at 10% O₂ show a trend towards where it is high in the controls, medium in the Bosentan treated mice and low in the BQ-788 treated mice. The difference is significant (P<0.005) between all the three groups. The error bar indicates ± standard error.