Fig 4:

EDNRB expression and phenotype associated with tissue specific KO of this gene. a) Tissues wise EDNRB expression in humans. RPKM value for EDNRB were obtained from GTEx portal (https://gtexportal.org/)). b) Diverse role of EdnrB identified using tissue specific KO mice (red line) and levels measured in the whole blood/serum (blue line). Middle zone depicts the phenotype related to the tissue specific KO study (color-coded). For the role of EdnrB in blood, ‘eryptosis’ was retrieved from rescued global EdnrB KO mice. The ‘cerebral function’ was indicated by ‘cerebral vasoconstriction reactions’ and the EDNRB level measured in the blood serum of CMS patients. All indicate a direct or indirect involvement in hypoxia adaptation. The respective numbers indicate the related references: 1, Ge et al. (2006); 2, Miller et al. (2017); 3, Kelland et al. (2010a); 4, Bagnall et al. (2006); 5, Kelland et al. (2010b); 6, Wu et al. (2016); 7, Foller et al. (2010); 8, Present study.