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Inhibition of GCPII by urea- and carbamate-based compounds.
| Cmpd | Structure | Stereochemistry | IC50 (nM) | Cmpd | Structure | Stereochemistry | IC50 (nM) |
|---|---|---|---|---|---|---|---|
| ZJ-43 |  |
(S,S) | 0.50 ± 0.11 | 7 |  |
(S,S) | 0.65 ± 0.11 |
| 4 |  |
(R,S) | 15.9 ± 9.9 | 8 |  |
(R,S) | 8.9 ± 0.1 |
| 5 |  |
(S,S) | 16.9 ± 7.2 | 9 |  |
(S,R) | 630 ± 8 |
| 6 |  |
(R,S) | 531 ± 111 | 10 |  |
(R,R) | 8530 ± 20 |
IC50 values were calculated from the inhibition curves using non-linear analysis and are shown in the format mean ± standard deviation.
