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. Author manuscript; available in PMC: 2020 Mar 1.
Published in final edited form as: Am J Med Genet A. 2018 Dec 24;179(3):467–474. doi: 10.1002/ajmg.a.61002

Figure 1: Results of genetic association tests:

Figure 1:

Quantile-quantile plots depict the observed log10-transformed p-values (y-axis) vs. the expected distribution of p-values (x-axis) under the null hypothesis of no association. Each point represents the evidence of genetic association for a specific craniofacial enhancer. The top panels show results for CP and the bottom panels show results for CL/P. Left panels show results of CMC scans, and right panels show results of SKAT scans. Horizontal dashed lines represent the threshold for suggestive association (p-value < 0.004). The horizontal dotted line represents the Bonferroni threshold for statistical significance.