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. Author manuscript; available in PMC: 2020 Jan 1.
Published in final edited form as: Psychopharmacology (Berl). 2018 Sep 20;236(1):239–250. doi: 10.1007/s00213-018-5022-5

Table 1.

Synaptic NMDAR effects related to fear extinction

Receptor/drug Species Process Effect Circuit Reference
GluN (DCS) rat LFS-primed LTP Correlate of
fear
extinction		 hippocampus-
mPFC		 (Inoue et
al. 2013)
GluN1/2B
(Glyx-13)		 rat LTP-like
metaplasticity		 Correlate of
fear
extinction-
CFC		 PFC,
hippocampus		 (Burgdorf
et al.
2015a)
GluN1/2B
(Ro25–6981)		 rat LTD Correlate of
fear
extinction-
DFC		 Lateral
amygdala		 (Dalton et
al. 2012)
GluN mouse SC-CA1 LTP Correlate of
fear
extinction-
CFC		 Hippocampus (Kim et al.
2011)
GluN1 mouse stimulation-
evoked synaptic
NMDAR-
mediated
currents		 Correlate of
fear
extinction-
DFC		 IL (Holmes et
al. 2012)
Aquaporin-4 mouse Enhanced
GluN2B-
dependent CA3-
CA1 LTD		 Correlate of
fear
extinction-
DFC		 Local
astrocytes		 (Wu et al.
2017)