Table 3:

Charlson Comorbidity Index (CCI) and Risk of Mortality, by Frailty, Age, Race and Sex among Kidney Transplant (KT) Candidates (n=2,086). The CCI is modified for ESRD patients and we defined a high comorbidity burden as a CCI score of ≥2 and low comorbidity burden as a CCI score of 0 or 1.

Risk of Mortality
	1-point increase in CCI score, HR (95% CI)	High Comorbidity Burden, HR (95% CI)
Overall risk	1.08 (1.03–1.13)	1.38 (1.01–1.89)
Frailty
Nonfrail	1.10 (1.05–1.15)	1.66 (1.17–2.35)
Frail	1.02 (0.92–1.12)	0.75 (0.44–1.29)
P for interaction	0.16	0.01
Age
<65	1.10 (1.05–1.15)	1.75 (1.22–2.52)
≥65	1.02 (0.92–1.13)	0.97 (0.60–1.56)
P for interaction	0.16	0.04
Race
Non-African American	1.13 (1.06–1.21)	1.72 (1.16–2.55)
African American	1.04 (0.97–1.11)	1.03 (0.67–1.59)
P for interaction	0.31	0.06
Sex
Male	1.10 (1.05–1.15)	1.53 (1.05–2.24)
Female	1.02 (0.93–1.13)	1.17 (0.74–1.85)
P for interaction	0.17	0.33