. Author manuscript; available in PMC: 2020 Mar 20.

Published in final edited form as: ACS Chem Neurosci. 2018 Aug 13;10(3):1055–1065. doi: 10.1021/acschemneuro.8b00346

Table 1.

Amino Acids Residues Involved in Wild-Type Protein Interacting with MC4R Ligands^a

	α-MSH tetrapeptide	RM-493
residues	Glu100, Asp122, Asp126, Phe261, Trp258, His264	Glu100, Asp122, Asp126, Phe261, Trp258, His264, Asn123, Leu106, Asp111, Tyr276, Tyr268

Amino acid residues potentially involved in allosteric binding contributing to agonist specificity and potency in bold.