Table 2.
Mean log10 colony-forming unit (CFU)/ml of hetero-resistant vancomycin intermediate S. aureus (hVISA), methicillin resistant S. aureus (MRSA) and methicillin susceptible S. aureus (MSSA) isolates treated with oxacillin alone, vancomycin alone and oxacillin plus vancomycin combination in time-kill assays
| Organism | Growth control log10 CFU/ml ± SD |
Time kill assay aMean log10 CFU/ml ± SD |
||
|---|---|---|---|---|
| Oxacillin | Vancomycin | bOxacillin at ½ X MIC + vancomycin ½ X MIC | ||
| hVISA (n = 29) | 8.3 ± 0.3 | 6.5 ± 0.7 | 6.4 ± 0.5 | 5.0 ± 0.7 |
| MRSA (n = 10) | 8.1 ± 0.1 | 5.1 ± 0.3 | 4.6 ± 0.3 | 3.9 ± 0.4 |
| MSSA (n = 5) | 8.4 ± 0.3 | 3.7 ± 0.3 | 6.9 ± 0.2 | 3.6 ± 1.0 |
aAll data are presented as mean ± standard deviation (SD)
b1/2 MICs of oxacillin and vancomycin are derived from hVISAMIC of individual isolates as listed in Table 1