Table 1.
Baseline Characteristics of Intervention Participants and Matched Controls
| Intervention participants n = 776 |
Matched control patients n = 776 |
p value | |
|---|---|---|---|
| Age (mean/median (range)) | 57.2/59.0 (18–96) | 59.7/60 (19–97) | 0.0005 |
| Race/ethnicity* | < 0.0001 | ||
| White, no. (%) | 522 (67.3) | 593 (76.4) | |
| Black, no. (%) | 108 (13.9) | 63 (8.1) | |
| Hispanic, no. (%) | 112 (14.4) | 79 (10.2) | |
| Other, no. (%) | 34 (4.4) | 41 (5.3) | |
| Sex | 0.0005 | ||
| Female, no. (%) | 518 (66.6) | 581 (74.9) | |
| Clinical characteristics | |||
| Charlson Index (mean/median) | 1.5781/1.0000 | 1.4867/1.0000 | 0.6458 |
| No. of medications† (mean/median) | 10.1/8.0 | 10.2/8.0 | 0.83 |
| No. of medications at 1 year† (mean/median) | 11.5/10.0 | 11.3/9.0 | 0.71 |
| No. of medical problems† (mean/median) | 9.1/8.0 | 9.2/8.0 | 0.75 |
| No. of medical problems at 1 year†(mean/median) | 10.2/9.0 | 10.2/9.0 | 0.92 |
| Condition treated with target medication‡ | Overall target condition comparison 0.3389 | ||
| Hypertension, no. (%) | 411 (53.0) | 442 (57.0) | 0.1134 |
| Insomnia, no. (%) | 143 (18.4) | 132 (17.0) | 0.4701 |
| Depression, no. (%) | 122 (15.7) | 120 (15.5) | 0.9136 |
| Diabetes, no. (%) | 100 (12.9) | 82 (10.5) | 0.1415 |
*Race/ethnicity data based on coded fields in the EHR
†Medications and documented problems extracted from the EHR medication and problem lists at the time the target medication was prescribed and 1 year following the target prescription date
‡Treatment indication based on chart and not patient self-report