Table 2.

Documented Symptoms and Drug Discontinuations, Intervention vs. Control

	Intervention participants n = 776	Control patients n = 776	p value
Total symptoms collected by IVR system	997	NA
Total symptoms discussed by pharmacist	1018	NA
Related to target medication—probable	188 (18.5%)	NA
Related to target medication—possible	479 (47.1%)	NA
Related to target medication—unlikely	351 (34.5%)	NA
Severity of pharmacist-confirmed possible and probable symptoms (N = 668)
Mild	266 (39.8%)	NA
Significant	400 (59.9%)	NA
Life-threatening	1 (0.15%)	NA
Total symptoms documented by MD in notes	277	164	< 0.0001
Number of symptoms per 100 patients	36	21	< 0.0001
Number of patients with symptoms documented by MD	177	122	< 0.0001
Total unique symptoms documented (including IVR documented and MD notes)	1303	164	< 0.0001
Total unique patients with symptoms documented (including IVR documented)	448	120	< 0.0001
Total unique symptoms documented by MD or RPh as probably or possibly related to the drug	753	164	< 0.0001
Total unique patients with symptoms documented by MD or RPh as probably or possibly related to the drug	425	120	< 0.0001
Drug discontinuations (CPOE d/c code reason)	N = 5106* No. (%)	N = 5897† No. (%)
Discontinuations 1 year from prescription	1694 (33.2)	1977 (33.5)	0.70
Discontinuations due to adverse event‡	254 (15.0)	217 (11.0)	0.0003

^*Missing data on target medication discontinuations for 37 patients

^†Missing data on target medication discontinuations for 88 patients

^‡Discontinuation due to an adverse event as a coded justification in the EHR