Figure 2.

Genetic rescue scheme. Mice lacking Fshb show sexually dimorphic phenotypes (red box). The features of HFSHB+ mice were shown in blue box. HFSHB+ mice by themselves do not exhibit any overt phenotypes. The Fshb null male mice are typically intercrossed with HFSHB+ transgenic female mice to eventually generate Fshb^−/− HFSHB⁺ mice. The HFSHB⁺ transgene fully rescues both male and female Fshb null mice (purple boxes).