Table 3.
Molecules associated with the blockade of MDSC expansion and recruitment.
| Molecules | Cancer type | Phenotype | Species | References |
|---|---|---|---|---|
| VITAMIN DERIVATIVES | ||||
| 1α,25-hydroxy vitamin D3 | HNSCC | MDSCs | Human | (109) |
| ATRA | Fibrosarcomas | MDSCs | Mouse | (110) |
| Mammary adenocarcinomas | MDSCs | Mouse | (110) | |
| Renal cell carcinoma | MDSCs | Human | (111) | |
| Vitamin D | CLL | CD14+HLA-DRlow MDSCs | Human | (112) |
| AMINO-BISPHOSPHONATE | ||||
| ZA | Mesothelioma | MDSCs | Mouse | (113) |
| Myeloma | MDSCs | Mouse | (114) | |
| Pancreatic cancer | CD15+CD11b+ MDSCs | Human | (115) | |
| Pancreatic cancer | MDSCs | Mouse | (115) | |
| Breast cancer | MDSCs | Mouse | (116) | |
| ANTIBODIES | ||||
| Anti-VEGFR-2 Ab | Melanoma and prostate tumor | M-MDSCs | Mouse | (117) |
| Anti-Gr1 Ab | Lung cancer | MDSCs | Mouse | (118) |
| Myeloma | MDSCs | Mouse | (119) | |
| MD5-1 mAb | Lymphoma | MDSCs | Mouse | (120) |
| DS-8273a mAb | Advanced cancers | MDSCs | Human | (121) |
| Anti-CD33 Ab | Myelodysplastic syndrome | CD33+HLA-DR−Lin−MDSCs | Human | (122) |
| Anti-KIT mAb | Colon cancer | M-MDSCs | Mouse | (123) |
| Anti-ENO1 mAb | Pancreatic ductal adenocarcinoma | MDSCs | Mouse | (124) |
| Anti-DC-HIL mAb | Colorectal cancer | M-MDSCs | Mouse | (125) |