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. 2019 Feb 7;10:178. doi: 10.3389/fimmu.2019.00178

Figure 2.

Figure 2

CIA severity was ameliorated by VD treatment. (A) Representative pictures showing the paw, lymph nodes (LN) and spleen (SP) from two groups. (B) Representative CT imaging of feet in CIA mice of model group and VD-treated group in 60-day after CII/CFA immunization. (C) Hematoxylin and eosin (HE)-stained sections and evaluation of synovitis, pannus, and erosion of knee joints in CIA mice 60 days after primary immunization. Red arrows: lymphocytes infiltration; Yellow arrows: destruction of joint cartilage. Scale bar, 40X. (D) The pathology scores of HE stained section were shown. Four mice were included in each group and data were combined from two independent experiments (n = 4). (E) CII-specific IgG subsets in sera harvested day 30 and day 60 after immunization were measured by ELISA (n = 5). *P < 0.05, **P < 0.01, ****P < 0.0001 VD-treated group in comparison to CIA model group.