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The pem1Δ/Δ pem2Δ/Δ mutant is hypervirulent. Mice were infected via the lateral tail vein with 3 × 105 wild type (WT), pem1Δ/Δ pem2Δ/Δ, or pem1Δ/Δ::PEM1 pem2Δ/Δ::PEM2 cells. Mice infected with the pem1Δ/Δ pem2Δ/Δ mutant succumb to infection more rapidly than those infected with wild type C. albicans [∗∗p < 0.01 compared to wild-type; log-rank (Mantel–Cox) test]. The number of mice representing each strain is shown in parenthesis beside each strain.
