Table 1.
Metabolite concentration ratios compared to control (SHAM-CT) and FDR values per comparison.
| Ratios to CT | SHAM CT | SHAM SR | ROT CT | ROT SR | FDR | ||
|---|---|---|---|---|---|---|---|
| one-way ANOVA | Multivariate ANOVA | ||||||
| SR | Rotenone | ||||||
| Isoleucine | 1.00 | 1.22 | 1.12 | 1.35 | 0.021 | 0.039 | 0.300 |
| Leucine | 1.00 | 1.26 | 1.18 | 1.40 | 0.021 | 0.039 | 0.261 |
| Valine | 1.00 | 1.21 | 1.12 | 1.33 | 0.014 | 0.061 | 0.285 |
| Alpha-AAA | 1.00 | 0.87 | 0.72 | 0.92 | 0.032 | 0.432 | 0.862 |
| Kynurenine | 1.00 | 0.79 | 1.15 | 0.72 | 0.028 | 0.014 | 0.799 |
| PCaaC30:0 | 1.00 | 1.19 | 1.17 | 1.36 | 0.021 | 0.622 | 0.275 |
| PCaaC34:1 | 1.00 | 1.21 | 1.17 | 1.43 | 0.049 | 0.529 | 0.275 |
| PCaaC40:2 | 1.00 | 1.02 | 1.13 | 1.48 | 0.028 | 0.771 | 0.072 |
| PCaaC42:4 | 1.00 | 1.01 | 1.00 | 1.26 | 0.028 | 0.871 | 0.489 |
| PCaaC38:3 | 1.00 | 1.10 | 1.27 | 1.49 | 0.034 | 0.357 | 0.128 |
Statistical analysis with one-way ANOVA showed 10 metabolites with significant differences (FDR < 0.05) listed here. Multivariate ANOVA showed 3 metabolites significantly altered (highlighted in bold) due to SR in comparison to SHAM-CT and no differences for rotenone lesion.